Plasma Therapy Using DBD Plasma Technology in Physiotherapy – A Scientific Review and Clinical Applications
Introduction
DBD Plasma (Dielectric Barrier Discharge Plasma) is one of the latest technologies utilized in physiotherapy and medicine, leveraging the unique properties of plasma to enhance therapeutic processes. Plasma, as the fourth state of matter, consists of electrically charged particles such as electrons and ions. Due to its ability to stimulate biological processes in the body—particularly in reducing inflammation, accelerating tissue regeneration, and improving muscle function—plasma has become a powerful tool in the field of medical science.
DBD Plasma, which is generated using electrical energy at low temperatures, is a safe and non-invasive technology for treating musculoskeletal issues and body inflammations. This article explores the operational mechanisms, advantages, and applications of DBD Plasma in physiotherapy, along with the notable devices used in this field.
Mechanism of DBD Plasma Operation
DBD Plasma operates by using strong electric fields and high voltage to convert common gases like air, nitrogen, or argon into plasma. This conversion is an ionization process in which gases absorb energy from the electric field and transition into the plasma state. During this process, gas molecules are broken down into electrons, ions, and active molecules. These active particles directly affect cells and tissues in the body, stimulating various biological processes.
Production of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS)
One of the primary mechanisms by which DBD Plasma operates is through the generation of Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS). These molecules include nitric oxide, hydrogen peroxide, atomic oxygen, and nitrite oxide, which, due to their strong chemical properties, influence various biological processes:
- Reactive Oxygen Species (ROS) can cause changes in cellular membranes, proteins, and DNA. These molecules play a crucial role in tissue repair and immune responses by stimulating cellular signaling processes. Additionally, ROS are recognized as potent antibacterial and disinfectant agents that can deactivate bacteria and viruses.
- Reactive Nitrogen Species (RNS) have similar effects, and aside from their antibacterial properties, they are effective in dilating blood vessels and enhancing localized blood flow. These molecules, by influencing cellular signaling pathways and regulating inflammatory responses, help reduce inflammation and accelerate the healing process.
Production of Nitric Oxide (NO) and Its Effects on the Body
Nitric oxide (NO) is one of the key molecules produced by DBD plasma. This molecule acts as a biochemical mediator in many cellular processes in the body and plays an important role in vascular physiology and immune system regulation:
- Vasodilation: NO promotes the dilation of blood vessels, which helps increase blood flow and improve oxygen delivery to damaged tissues. This feature is crucial for wound healing, as well as reducing pain and inflammation.
- Regulation of Immune Responses: NO can assist in regulating the body’s immune responses and reduce both acute and chronic inflammation. These effects are especially beneficial in treating inflammatory injuries and chronic musculoskeletal pain.

Collagen Production and Growth Factor Stimulation
One of the most important effects of DBD plasma on body tissues is the stimulation of collagen production and growth factors. This property accelerates the repair processes and regeneration of damaged tissues:
- Fibroblast Stimulation: DBD plasma can stimulate fibroblasts, which are the primary cells responsible for collagen production. These cells help strengthen tissue structure and increase its resilience by producing more collagen and elastin.
- Increase in Growth Factors: DBD plasma promotes the secretion of growth factors such as Epidermal Growth Factor (EGF) and Vascular Endothelial Growth Factor (VEGF). These factors accelerate the growth and regeneration of new cells and aid in the formation of blood vessels in the damaged areas.


Disinfection and Reduction of Infection Risk
DBD plasma is recognized as a highly effective disinfecting technology. This method creates a clean and sanitized environment for treatment by generating electrons, ions, and active species:
- Destruction of Bacteria, Viruses, and Fungi: DBD plasma, by inducing oxidative conditions and producing active molecules, can deactivate bacteria, viruses, and fungi. This feature helps reduce the risk of secondary infections and accelerates the wound healing process.
- No Damage to Healthy Tissue: One of the advantages of DBD plasma is its ability to eliminate infections without causing damage to healthy tissue. This makes it suitable for treating a wide range of skin conditions and wounds.

Scientific Studies and Notable Articles on DBD Plasma
The technology of DBD Plasma and its biological effects on the body have been the subject of extensive research worldwide. Numerous scientific articles and clinical studies have explored the applications of this technology in medicine and physiotherapy. Below are some examples of these studies:
- A study published in Plasma Medicine: This study demonstrated that DBD plasma can help reduce chronic inflammation and accelerate wound healing. Additionally, the antibacterial effects of plasma in reducing infections caused by wounds were confirmed.
- Research published in the Journal of Clinical Plasma Medicine: These articles examined the role of DBD plasma in stimulating collagen production and enhancing growth factors. The results showed that the use of DBD plasma can facilitate the healing of chronic wounds and accelerate tissue regeneration.
- A study published in IEEE Transactions on Plasma Science: This research focused on the safety of using DBD plasma in treating skin issues and revealed that this method is safe for various skin types with minimal side effects.
These studies indicate the high efficacy of DBD plasma in physiotherapy and medical treatments, particularly due to its non-invasive nature and high safety, making this technology rapidly become one of the main tools in modern medicine.
Benefits of Using DBD Plasma in Physiotherapy
DBD Plasma offers numerous benefits in physiotherapy treatments due to its unique characteristics. As a non-invasive and safe method, it has captured the attention of many medical professionals. Below are some of the key benefits of using DBD plasma:
- Non-invasive and No Need for Surgery:
DBD plasma is a non-invasive method that helps reduce pain and inflammation without the need for surgery or skin incisions. This feature allows patients to benefit from treatment without the concern of surgical risks. - Rapid Reduction of Pain and Inflammation:
By generating electric fields and stimulating ion channels, DBD plasma can quickly reduce pain and inflammation. This feature is particularly effective in alleviating chronic pain and inflammation resulting from sports injuries and musculoskeletal conditions. - Accelerates Tissue Regeneration and Healing:
DBD plasma stimulates the body’s natural processes, helping accelerate cell regeneration and wound healing. This technology enhances collagen production and growth factors, which speeds up the repair of damaged tissues. - Antibacterial and Reduces the Risk of Infection:
One of the unique features of DBD plasma is its ability to destroy bacteria and viruses. This capability reduces the risk of infection and accelerates the wound healing process. - High Safety and Suitable for All Skin Types:
DBD plasma is safe for all skin types and can even be used to treat individuals with sensitive skin or specific skin conditions. This method carries out the healing process without damaging healthy tissue.
No Need for Recovery Time
After using DBD plasma, patients can immediately return to their daily activities without the need for prolonged rest or recovery periods. This feature is particularly beneficial for athletes and individuals looking for a quick return to their regular activities.
Clinical Applications of DBD Plasma in Physiotherapy
DBD plasma has widespread applications in various physiotherapy treatments. From alleviating muscle and joint pain to improving wounds and reducing inflammation, this technology is increasingly used as one of the effective and non-invasive treatment methods. Below are some of the most important clinical applications of this method:
- Treatment of Chronic and Acute Musculoskeletal Pain
DBD plasma is highly effective in reducing both chronic and acute pain caused by musculoskeletal injuries. This method is particularly beneficial for alleviating pain from conditions like arthritis, tendinitis, bursitis, and other muscular issues. - Improvement of Chronic and Surface Wounds
By stimulating the body’s repair processes and enhancing collagen production, DBD plasma helps in faster healing of chronic and surface wounds. This method is especially effective for hard-to-heal wounds and preventing recurrent infections. - Reduction of Chronic and Acute Inflammation
DBD plasma helps reduce both chronic and acute inflammation in the body by affecting ion channels and inhibiting inflammatory substances. This feature is particularly helpful for patients suffering from long-term inflammation. - Improvement of Skin Conditions and Reduction of Skin Infections
Due to its disinfectant properties, DBD plasma is effective in improving skin wounds and reducing superficial infections. This feature has made DBD plasma a useful method for treating acne, bedsores, and various skin conditions.
Conclusion
DBD plasma has become a prominent and effective technology in physiotherapy, gaining a significant place in the field of medicine. This non-invasive and safe method, by reducing pain, accelerating repair processes, and improving wound healing, has become one of the main choices in modern treatments. Advanced DBD plasma devices with adjustable energy settings enable healthcare providers to offer personalized treatments for each patient, yielding better outcomes. With future scientific advancements, this technology will play an even greater role in the world of physiotherapy and will continue to be recognized as a key tool in non-invasive treatments.